Alzheimer trial at USF shows promising results for memory loss reversal

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TAMPA, Fla. ‘ Results from a two-month clinical study on the ‘ M.D. and Director of Clinical Research at USF.

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TAMPA, Fla. ‘ Results from a two-month clinical study on the effects of a medical device on patients suffering from Alzheimer’s showed a lot of promise for the future of overcoming the neurodegenerative disease.

The study describes Alzheimer’s Disease as a brain disease which leads to memory loss, issues with language and other serious symptoms. It destroys brain cells which allow for thinking, learning and memory, which can limit patients’ abilities to perform daily activities over time.


Publisher: 10NEWS
Date: 9/24/2019 8:14:55 PM
Twitter: @10NewsWTSP
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Swedish mutant APP-based BACE1 binding site peptide reduces APP ‘-cleavage and cerebral A’ levels in Alzheimer’s mice

BACE1 activity was assayed in the absence and presence of APPsweBBP or TAT-APPsweBBP at 0.05, 0.5, 5 and 20’M and percentage inhibition of the enzyme was determined.

To further predict the potential interactions between TAT-APPsweBBP and BACE1, 3-D structure modeling and enzyme-substrate interactions were analyzed via online server [email protected] v1.5.1 (http://mobyle.rpbs.univ-paris-diderot.fr/). (A) The modeling suggested that after fusion with HIV-1 TAT protein transduction domain, the resulting TAT-APPsweBBP possesses more ‘-helices than APPsweBBP alone. Moreover, the less folded BACE1 cleavage site of TAT-APPsweBBP outside the ‘-helix (L-D, arrow), may create a less sterically hindered and larger site for BACE1 binding, higher binding affinity and more efficient enzymatic digestion compared to TAT-APPwtBBP (M-D, arrow). (B) Owing to more ‘-helical content, the ‘-cleavage site of TAT-APPwtBBP is less accessible within the ‘-helix structure.

Publisher: Scientific Reports
Date: 2015-06-19
Author: Song Li
Twitter: @SciReports
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Publisher: Daily Nous
Date: 2014-09-29 08:35
Twitter: @DailyNousEditor
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News for March 2016 – ConsumerAffairs

A federal judge says it isn’t and yesterday struck down the U.S. government’s determination that MetLife needs to build up its capital reserves and submit to tight regulation to ensure its financial well-being.

“From the beginning, MetLife has said that its business model does not pose a threat to the financial stability of the United States,” the company’s chief executive, Steven Kandarian, said in a statement.

The decision is seen as a victory for big business, and it was quickly followed by a report that General Electric, which owns Genworth,’might be next in line to challenge its designation as “systemically important” to the U.S. economy. Wall Street is also pressing’AIG and Prudential to respond.’

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