USF Health researchers use firefly glow enzyme to better understand COVID

This entry was posted in News on by .


Researchers at USF Health are lighting up their study in the hope to learn more about COVID-19 and how it could affect different people.

Read More.

Dr. Tom McDonald, a USF Health professor of Medicine in Cardiology and Molecular Pharmacology & Physiology, explains rather than handling the live virus in the study, researchers are using a safer, COVID-19 pseudotype, which also holds the same enzyme that gives fireflies their glow, called luciferase.

‘I like to think of it as a sheep in wolf’s clothing,’ said McDonald. ‘It’s a good surrogate for whether or not the virus can get into a particular cell type, and you can actually quantify it. You say it gets in more, it gets in less, that type of comparison is easily made with the firefly luciferase.’


Publisher: WFTS
Date: 2020-07-22T21:47:20.199
Author: Author link
Twitter: @abcactionnews
Reference: Visit Source (Read Article)

Were you following this:

Chemical glow from fireflies could help trace spread of COVID-19

Publisher: 83Degrees
Twitter: @83DegreesMedia
Reference: Visit Source (Read Article)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Malaria parasites are evolutionarily prepared to resist drug attack. Resistance is emerging to even the latest frontline combination therapies, which target the blood stages of the Plasmodium parasite. As an alternative strategy, Antonova-Koch et al. investigated the possibilities of drugs against liver-stage parasites (see the Perspective by Phillips and Goldberg). To do so, they devised a luciferase-reporter drug screen for the rodent parasite Plasmodium berghei. Three rounds of increasingly stringent screening were used. From this regime, several chemotypes that inhibit Plasmodium mitochondrial electron transport were identified. Excitingly, several new scaffolds, with as-yet-unknown modes of action but solely targeting the parasites’ liver stages, emerged as promising drug leads for further development.

Publisher: Science
Date: 2018-12-07
Reference: Visit Source (Read Article)

Video